Principal Scientist - Discovery Pharmaceutical Sciences
Job Description New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment. Discovery Pharmaceutical Sciences (DPS) enables drug discovery and drug product development through application of pharmaceutical science and drug delivery research from target identification through clinical candidate selection for both small and large molecules. DPS influences molecular design of these clinical candidates through physicochemical property profiling and application of insights to better understand and resolve drug product developability risks. We further utilize our expertise to identify and develop solid state phases, develop and study prototype formulations intended for clinical use, and deliver robust Good Laboratory Practice formulations. In aggregate our team enables the transition of the right molecules from discovery to clinical formulation development with clinical formulation strategies in place. DPS in West Point, PA is seeking a Principal Scientist (R5) to join our department. The role will report to the West Point DPS Director and will be expected to identify and champion impactful pipeline-driven innovations to solve unique Discovery program challenges across modalities. The candidate will be expected to inspire scientific rigor within the team and bring novel tools to aid in keeping DPS at the forefront of pharmaceutics assessment in Discovery. Development of subject matter experts and technical depth within the group will be accomplished through technical mentorship of scientists and teams on the design, execution, and documentation of experiments to evaluate the potential liabilities in novel chemical matter and to prototype standard and novel formulations to inform on downstream risks. The candidate should possess scientific knowledge and / or experience related to various aspects of drug product development (i.e. formulation and process development, biopharmaceutics, analytical methods, regulatory considerations, competitive landscape) with a drive to apply novel technologies while working at the laboratory bench. The successful candidate will be expected to work within DPS and across our Company to analyze, coordinate, plan, and lead teams to advance pipeline-driven novel drug delivery solutions. This position is expected to drive communications both verbally and through written documents and reports, to the local team, across functions, and external to our Company. The candidate should have a creative passion for identifying and applying effective drug delivery technologies and pharmaceutics methods as well as a track record of driving results and rapidly progressing from idea conception to in-vitro & in-vivo evaluation. As part of our Company's emphasis on innovation, the successful candidate also will actively explore external (commercial and academic) opportunities in order to engage new technologies related to drug delivery, pharmaceutics and other areas relevant to our Compan's drug discovery/development programs. The candidate should be forward thinking and continue to search for the opportunities to gain efficiencies. Strong communication skills as well as good documentation practices are essential. The successful candidate will be able to work in a fast-paced team environment. Primary
Responsibilities:
Design and characterize novel therapeutics in the context of drug product development, formulations; Execute thorough developability assessments. Works closely with protein scientists, medicinal chemists and discovery teams throughout all stages of discovery to build key structure-property relationships across multiple drug modalities to identify optimal candidates for development Design enabling preclinical formulations (drug delivery) for pharmacology and toxicology studies Optimize preclinical drug candidates' solid state phase (pharmaceutics, stable polymorph ID, salt selection, etc.) Deliver key data sets for development candidate evaluation (Developability Assessment) for small molecules, peptides and biologics Identify new and impactful drug delivery and pharmaceutics technologies that enable the Company pipeline Provide leadership/mentorship for junior scientists in the laboratory Influence the direction of discovery teams in order to identify and progress optimal drug candidates of all modalities Must excel in a team environment, where they also will collaborate with development functions (preformulation, chemistry, formulation, analytical, and biopharmaceutics research) in order to prepare early data sets that can be translated to clinical formulation development and ultimately quality drug products. Expected to effectively present their work at team meetings as well as promoteour Company science through publications and presentations/lectures. The successful candidate must be able to balance their core laboratory research, team representation, and participation in key initiatives. Education Minimum Requirements:
Ph.D. with +6 years or M.S. with +8 years in pharmaceutical sciences, chemistry, chemical / biochemical engineering, or related disciplines. Required Experience and Skills Excellent verbal and written communication skills are required. Strong leadership/interpersonal skills and a motivation to work in a team environment with cross-functional interactions are essential. Familiarity with early development and commercialization challenges through relevant development experience Strong organizational and technical problem-solving abilities Ability to work in a fast-paced team environment Learning and growth mindset; willingness to explore and master new analytical techniques and formulation processes. Desired Experience and Skills Demonstrated experience solving program challenges by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, and/or engineering. Candidates with experience in pre-clinical / clinical formulation development and physico-chemical characterization of small molecules, peptides, oligonucleotides, bioconjugation and/or biologics are preferred. Candidates with specific experience with drug delivery are also preferred, including design, preparation and analysis of lipid nanoparticle formulations, enabled oral solid dosage forms, and parenteral formulations. Advanced data analysis and visualization skills We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us--and start making your impact today. NOTICE FOR INTERNAL APPLICANTS In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions. If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor. US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. For more information about personal rights under Equal Employment Opportunity, visit:
EEOC Poster EEOC GINA Supplement OFCCP EEO Supplement Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
Shift:
Valid Driving License:
Hazardous Material(s):
Number of Openings:
1.
Salary Range:
$100K -- $150K
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
Responsibilities:
Design and characterize novel therapeutics in the context of drug product development, formulations; Execute thorough developability assessments. Works closely with protein scientists, medicinal chemists and discovery teams throughout all stages of discovery to build key structure-property relationships across multiple drug modalities to identify optimal candidates for development Design enabling preclinical formulations (drug delivery) for pharmacology and toxicology studies Optimize preclinical drug candidates' solid state phase (pharmaceutics, stable polymorph ID, salt selection, etc.) Deliver key data sets for development candidate evaluation (Developability Assessment) for small molecules, peptides and biologics Identify new and impactful drug delivery and pharmaceutics technologies that enable the Company pipeline Provide leadership/mentorship for junior scientists in the laboratory Influence the direction of discovery teams in order to identify and progress optimal drug candidates of all modalities Must excel in a team environment, where they also will collaborate with development functions (preformulation, chemistry, formulation, analytical, and biopharmaceutics research) in order to prepare early data sets that can be translated to clinical formulation development and ultimately quality drug products. Expected to effectively present their work at team meetings as well as promoteour Company science through publications and presentations/lectures. The successful candidate must be able to balance their core laboratory research, team representation, and participation in key initiatives. Education Minimum Requirements:
Ph.D. with +6 years or M.S. with +8 years in pharmaceutical sciences, chemistry, chemical / biochemical engineering, or related disciplines. Required Experience and Skills Excellent verbal and written communication skills are required. Strong leadership/interpersonal skills and a motivation to work in a team environment with cross-functional interactions are essential. Familiarity with early development and commercialization challenges through relevant development experience Strong organizational and technical problem-solving abilities Ability to work in a fast-paced team environment Learning and growth mindset; willingness to explore and master new analytical techniques and formulation processes. Desired Experience and Skills Demonstrated experience solving program challenges by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, and/or engineering. Candidates with experience in pre-clinical / clinical formulation development and physico-chemical characterization of small molecules, peptides, oligonucleotides, bioconjugation and/or biologics are preferred. Candidates with specific experience with drug delivery are also preferred, including design, preparation and analysis of lipid nanoparticle formulations, enabled oral solid dosage forms, and parenteral formulations. Advanced data analysis and visualization skills We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us--and start making your impact today. NOTICE FOR INTERNAL APPLICANTS In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions. If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor. US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. For more information about personal rights under Equal Employment Opportunity, visit:
EEOC Poster EEOC GINA Supplement OFCCP EEO Supplement Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
Shift:
Valid Driving License:
Hazardous Material(s):
Number of Openings:
1.
Salary Range:
$100K -- $150K
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
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